946062-02-8

Basic information

• Product Name: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine
• Synonyms: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine
• CAS NO: 946062-02-8
• Molecular Weight: 787.985
• Mol File: 946062-02-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine(946062-02-8)
• EPA Substance Registry System: 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-(N-tert-butoxycarbonyl)glycine(946062-02-8)

Safety Data

• Hazardous Substances Data: 946062-02-8(Hazardous Substances Data)

Upstream product

• 4530-20-5 BOC-glycine 
• 946062-01-7 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 31972-52-8 Boc-Gly-Gly-OH 

Downstream Products

• 946062-03-9 7-ethyl-10-O-t-butyldiphenylsilylcamptothecin-20-O-glycine hydrochloride 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR SYNTHESIS OF THERAPEUTIC NANOPARTICLES

Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

Process for preparing 7-ethyl-10-O-tert-butyldiphenyl silyl camptothecin-20-O-glycine hydrochloride

The invention relates to a process for preparing 7-ethyl-10-O-tert-butyldiphenyl silyl camptothecin-20-O-glycine hydrochloride. The process refers to improvement and optimization of the conventional process, and comprises the following preferred steps: (1

TREATMENT OF NEUROBLASTOMA WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN

The present invention relates to methods of treatment of neuroblastoma. The present invention includes administering polymeric prodrugs of 7-ethyl-10-hydroxycamptothecin to patients in need thereof.