(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

Base Information

Chemical Name:(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride
CAS No.:1104077-77-1
Molecular Formula:C₂₀H₁₇F₅N₂O₃*ClH
Molecular Weight:464.82
Hs Code.:

Synonyms:(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

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Technology Process of (S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

There total 2 articles about (S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: C₂₀H₁₅F₅N₄O₃

: 1104077-77-1
(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; In ethanol; water; at 24 - 28 ℃; for 5h; under 3345.86 Torr; Large scale reaction;
DOI:10.1021/op900216v

Reference yield:

: 1104077-76-0
3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

: 1104077-77-1
(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

Guidance literature:: With hydrogenchloride; triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 1.16667h; Product distribution / selectivity;