3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

Base Information

Chemical Name:3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one
CAS No.:1104077-76-0
Molecular Formula:C₂₀H₁₅F₅N₄O₃
Molecular Weight:454.356
Hs Code.:

Synonyms:3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

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Chemical Property of 3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

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Technology Process of 3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

There total 2 articles about 3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104077-74-8
(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

: 1104077-76-0
3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one; With 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - -70 ℃; for 1 - 1.25h;

With acetic acid; In tetrahydrofuran; toluene; at -70 - 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

: C₃₅H₃₉F₅N₄O₅S

: 1104077-76-0
3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

Guidance literature:: With acetic acid; In tetrahydrofuran; water; toluene; at -47 - 20 ℃;
DOI:10.1021/op900299c

Reference yield:

: 1104077-76-0
3-[(S)-2-azido-(R)-3-(3,5-difluoro-phenyl)-4,4,4-trifluoro-butyryl]-(S)-4-benzyl-oxazolidin-2-one

: 1104077-77-1
(S)-3-((2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)-4-benzyloxazolidin-2-one hydrochloride

Guidance literature:: With hydrogenchloride; triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 1.16667h; Product distribution / selectivity;