HEXAMETHYLENE-BIS-[DIMETHYL-(3-PHTHALIMIDOPROPYL)AMMONIUM]DIBROMIDE

Base Information

• Chemical Name: HEXAMETHYLENE-BIS-[DIMETHYL-(3-PHTHALIMIDOPROPYL)AMMONIUM]DIBROMIDE
• CAS No.: 21093-51-6
• Molecular Formula: C32H44Br2N4O4
• Molecular Weight: 708.534
• Mol file: 21093-51-6.mol

Synonyms:Hdmppa;Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide;W-84;W-84 dibromide;

Chemical Property of HEXAMETHYLENE-BIS-[DIMETHYL-(3-PHTHALIMIDOPROPYL)AMMONIUM]DIBROMIDE

Chemical Property:

• PSA: 74.76000
• LogP: -2.04400
• Storage Temp.: −20°C
• Solubility.: DMSO: ~11 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

W-84 dibromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Uses: W-84 Dibromide is a potent allosteric modulator of muscarinic receptors.

Technology Process of HEXAMETHYLENE-BIS-[DIMETHYL-(3-PHTHALIMIDOPROPYL)AMMONIUM]DIBROMIDE

There total 3 articles about HEXAMETHYLENE-BIS-[DIMETHYL-(3-PHTHALIMIDOPROPYL)AMMONIUM]DIBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1 ,6-dibromohexane (629-03-8) + N,N-dimethyl-N-(3-phthalimidopropyl)amine (13474-65-2) → W 84 (21093-51-6)

Guidance literature:

In acetonitrile; for 0.35h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.01.035

Reference yield:

phthalic anhydride (85-44-9) → W 84 (21093-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / p-TsOH / toluene / 0.5 h / 115 °C / microwave irradiation

2: 97 percent / KI; K₂CO₃ / 2 h / 100 °C / microwave irradiation

With potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In toluene;

DOI:10.1007/s00706-006-0575-0

Reference yield:

1-amino-3-(dimethylamino)propane (109-55-7) → W 84 (21093-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / p-TsOH / toluene / 0.5 h / 115 °C / microwave irradiation

2: 97 percent / KI; K₂CO₃ / 2 h / 100 °C / microwave irradiation

With potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In toluene;

DOI:10.1007/s00706-006-0575-0

upstream raw materials:

1 ,6-dibromohexane

N,N-dimethyl-N-(3-phthalimidopropyl)amine

phthalic anhydride

1-amino-3-(dimethylamino)propane

Downstream raw materials:

benzene-1,2-dicarboxylic acid