2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

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Chemical Name:2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester
CAS No.:74275-91-5
Molecular Formula:C₂₈H₅₀O₄
Molecular Weight:450.703
Hs Code.:

Synonyms:2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

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Technology Process of 2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

There total 4 articles about 2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 693-03-8
n-butyl magnesium bromide

: 73651-43-1
di(-)menthyl 1-methylbutylidenemalonate

: 74275-91-5
2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

: 73636-71-2,73679-37-5
di(-)menthyl 1-methyl-1-propylpentylmalonate

Guidance literature:: With copper(l) chloride; In diethyl ether; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo01302a004

Reference yield:

: 2216-51-5
(-)-menthol

: 74275-91-5
2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) SOCl₂ / 1) 1,5h / reflux 2) 100-130 deg C / 4h

2: CuCl / diethyl ether / Ambient temperature

With thionyl chloride; copper(l) chloride; In diethyl ether;
DOI:10.1021/jo01302a004

Reference yield:

: 18795-91-0
2-(1-methylbutylidene)malonic acid diethyl ester

: 74275-91-5
2-(1-Methyl-butyl)-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / KOH / aq. ethanol / 4 h / Heating

2: 1) SOCl₂ / 1) 1,5h / reflux 2) 100-130 deg C / 4h

3: CuCl / diethyl ether / Ambient temperature

With potassium hydroxide; thionyl chloride; copper(l) chloride; In diethyl ether; ethanol;
DOI:10.1021/jo01302a004