2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CAS No.:167159-13-9
Molecular Formula:C₃₁H₄₃NO₅S
Molecular Weight:541.752
Hs Code.:

Synonyms:2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Chemical Property of 2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Technology Process of 2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

There total 7 articles about 2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1569-69-3
Cyclohexanethiol

: 167159-67-3
2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

: 167159-13-9
2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: With zinc(II) iodide; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jm9804477

Reference yield:

: 1071-71-2
ethyl 6-chloro-6-oxohexanoate

: 167159-13-9
2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / AlCl₃ / CH₂Cl₂ / 16 h / 0 - 25 °C

2: 97 percent / 10 percent ethanolic NaOH / 3 h / 25 °C

3: 1.) Et₃N, 2.) diethyl cyanophosphate / 1.) DMF, 25 deg C, 12 h, 2.) DMF, 25 deg C, 12 h

4: NaBH₄ / methanol / 12 h / 25 °C

5: 89 percent / ZnI₂ / CH₂Cl₂ / 1 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; diethyl cyanophosphonate; triethylamine; zinc(II) iodide; In methanol; dichloromethane;
DOI:10.1021/jm9804477

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 167159-13-9
2-<6-(cyclohexylthio)-6-(3,4-dimethoxyphenyl)-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / AlCl₃ / CH₂Cl₂ / 16 h / 0 - 25 °C

2: 97 percent / 10 percent ethanolic NaOH / 3 h / 25 °C

3: 1.) Et₃N, 2.) diethyl cyanophosphate / 1.) DMF, 25 deg C, 12 h, 2.) DMF, 25 deg C, 12 h

4: NaBH₄ / methanol / 12 h / 25 °C

5: 89 percent / ZnI₂ / CH₂Cl₂ / 1 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; diethyl cyanophosphonate; triethylamine; zinc(II) iodide; In methanol; dichloromethane;
DOI:10.1021/jm9804477