(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone

Base Information

• Chemical Name: (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone
• CAS No.: 161204-00-8
• Molecular Formula: C₁₉H₂₅NO₄S
• Molecular Weight: 363.478
• Mol file: 161204-00-8.mol

Synonyms:(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone

Chemical Property of (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone

There total 7 articles about (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione (161203-98-1) → (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone (161204-00-8)

Guidance literature:

With potassium permanganate; In acetic acid; for 78h; Ambient temperature;

DOI:10.1016/0040-4020(94)00982-Z

Reference yield: 24.0%

2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione (161203-98-1) → (1S,2S,5R,Sξ)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfoxide + (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone (161204-00-8)

Guidance literature:

With potassium permanganate; In acetic acid; for 23h; Ambient temperature;

DOI:10.1016/0040-4020(94)00982-Z

Reference yield:

N-(bromomethyl)phtalimide (5332-26-3) → (1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone (161204-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 36 h / 100 °C

2: 24 percent / KMnO₄ / acetic acid / 23 h / Ambient temperature

With potassium permanganate; In acetic acid;

DOI:10.1016/0040-4020(94)00982-Z

upstream raw materials:

2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione

N-(bromomethyl)phtalimide

(-)-menthol

(1S,2S,5R)-(+)-neomenthyl thiol