2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione

Base Information

• Chemical Name: 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione
• CAS No.: 161203-98-1
• Molecular Formula: C₁₉H₂₅NO₂S
• Molecular Weight: 331.479
• Mol file: 161203-98-1.mol

Synonyms:2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione

Chemical Property of 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione

There total 4 articles about 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(bromomethyl)phtalimide (5332-26-3) + (1S,2S,5R)-(+)-neomenthyl thiol (53273-24-8,196622-67-0,223653-15-4,173006-99-0) → 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione (161203-98-1)

Guidance literature:

at 100 ℃; for 36h;

DOI:10.1016/0040-4020(94)00982-Z

Reference yield:

(-)-menthol (2216-51-5) → 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione (161203-98-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / pyridine / 21 h / Ambient temperature

2: 57 percent / propan-2-ol / 15 h / Heating

3: 95 percent / 0.40 N NaOH / Heating

4: 85 percent / 36 h / 100 °C

With sodium hydroxide; In pyridine; isopropyl alcohol;

DOI:10.1016/0040-4020(94)00982-Z

Reference yield:

menthyl tosylate (2230-82-2) → 2-((1S,2S,5R)-2-Isopropyl-5-methyl-cyclohexylsulfanylmethyl)-isoindole-1,3-dione (161203-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / propan-2-ol / 15 h / Heating

2: 95 percent / 0.40 N NaOH / Heating

3: 85 percent / 36 h / 100 °C

With sodium hydroxide; In isopropyl alcohol;

DOI:10.1016/0040-4020(94)00982-Z

upstream raw materials:

N-(bromomethyl)phtalimide

(1S,2S,5R)-(+)-neomenthyl thiol

(-)-menthol

menthyl tosylate

Downstream raw materials:

(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl phthalimidomethyl sulfone