3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

Base Information

Chemical Name:3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester
CAS No.:1426857-13-7
Molecular Formula:C₂₃H₂₂N₄O₄
Molecular Weight:418.452
Hs Code.:

Synonyms:3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

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Chemical Property of 3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

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Technology Process of 3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

There total 4 articles about 3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 615-18-9
2-chloro-1,3-benzoxazole

: 1105044-81-2
3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

: 1426857-13-7
3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 3h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1426857-13-7
3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 8 h / 120 °C

2: N,N-dimethyl-formamide / 3 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1426857-13-7
3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 8 h / 120 °C

3.1: N,N-dimethyl-formamide / 3 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;