3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

Base Information

Chemical Name:3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid
CAS No.:1426856-42-9
Molecular Formula:C₂₂H₂₀N₄O₄
Molecular Weight:404.425
Hs Code.:

Synonyms:3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

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Chemical Property of 3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

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Technology Process of 3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

There total 5 articles about 3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.7%

: 1426857-13-7
3-(5-(4-(benzoxazol-2-ylamino)phenyl)pyrimidin-2-yloxy)-2,2-dimethylpropionic acid methyl ester

: 1426856-42-9
3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 18 - 25 ℃; for 3h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1426856-42-9
3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 8 h / 120 °C

2: N,N-dimethyl-formamide / 3 h / 110 °C

3: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 1105044-81-2
3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

: 1426856-42-9
3-(5-[4-(benzoxazol-2-ylamino)phenyl]pyrimidin-2-yloxy)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 110 °C

2: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

With water; sodium hydroxide; In methanol; N,N-dimethyl-formamide;