3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

Base Information

Chemical Name:3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester
CAS No.:1105044-81-2
Molecular Formula:C₁₆H₁₉N₃O₃
Molecular Weight:301.345
Hs Code.:

Synonyms:3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

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Chemical Property of 3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

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Technology Process of 3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

There total 2 articles about 3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.76%

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1105044-81-2
3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; at 120 ℃; for 8h;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1105044-81-2
3-((5-(4-aminophenyl)pyrimidin-2-yl)oxy)-2,2-dimethyl propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 8 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 2.1: |Suzuki Coupling;