cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester
CAS No.:1025061-37-3
Molecular Formula:C₂₄H₃₃N₃O₃
Molecular Weight:411.544
Hs Code.:

Synonyms:cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Chemical Property of cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Technology Process of cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

There total 5 articles about cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 247570-24-7
tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate

: 385802-40-4
2-methoxy-5-(pyridin-4-yl)benzaldehyde

: 1025061-37-3
cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate; 2-methoxy-5-(pyridin-4-yl)benzaldehyde; With acetic acid; In tetrahydrofuran; toluene; at 20 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; toluene; for 18h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; toluene;

Reference yield:

: 509143-03-7
cis-(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester

: 1025061-37-3
cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: acetic acid / tetrahydrofuran; toluene / 1.5 h / 20 °C

2.2: 18 h

With hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 1025061-37-3
cis-[4-(2-methoxy-5-pyridin-4-yl-benzylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 4 h / 45 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol

3.1: acetic acid / tetrahydrofuran; toluene / 1.5 h / 20 °C

3.2: 18 h

With diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;