(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

Base Information

Chemical Name:(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol
CAS No.:1378275-52-5
Molecular Formula:C₂₄H₃₉N₅O₄
Molecular Weight:461.605
Hs Code.:

Synonyms:(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

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Chemical Property of (S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

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Technology Process of (S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

There total 15 articles about (S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1378275-59-2
(S)-2-{3-[4-({2-amino-4-[1-(benzyloxy)hexan-3-ylamino]-6-methylpyrimidin-5-yl}methyl)-3-methoxyphenoxy]propylamino}ethanol

: 1378275-52-5
(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

Guidance literature:: (S)-2-{3-[4-({2-amino-4-[1-(benzyloxy)hexan-3-ylamino]-6-methylpyrimidin-5-yl}methyl)-3-methoxyphenoxy]propylamino}ethanol; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 7h;

With potassium carbonate; In water;

Reference yield:

: 230637-46-4
(S)-tert-butyl (1-hydroxyhexan-3-yl)carbamate

: 1378275-52-5
(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C

2: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

3: trifluoroacetic acid / 15 h / 120 °C

4: hydrogenchloride / water; methanol / 1 h / 20 °C

5: triethylamine / tetrahydrofuran / 0 °C

6: acetonitrile; water / 6 h / 80 °C

7: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 7 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1376514-43-0
(S)-tert-butyl 1-(benzyloxy)hexan-3-ylcarbamate

: 1378275-52-5
(S)-3-(2-amino-5-{4-[3-(2-hydroxyethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-ylamino)hexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

2: trifluoroacetic acid / 15 h / 120 °C

3: hydrogenchloride / water; methanol / 1 h / 20 °C

4: triethylamine / tetrahydrofuran / 0 °C

5: acetonitrile; water / 6 h / 80 °C

6: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 7 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;