Carbamic acid, [(1S)-1-(2-hydroxyethyl)butyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, [(1S)-1-(2-hydroxyethyl)butyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.:230637-46-4
Molecular Formula:C₁₁H₂₃NO₃
Molecular Weight:217.309
Hs Code.:
Mol file:230637-46-4.mol

Synonyms:(S)-tert-butyl (1-hydroxyhexan-3-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S)-1-(2-hydroxyethyl)butyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

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Technology Process of Carbamic acid, [(1S)-1-(2-hydroxyethyl)butyl]-, 1,1-dimethylethyl ester (9CI)

There total 4 articles about Carbamic acid, [(1S)-1-(2-hydroxyethyl)butyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 64197-80-4
(S)-(+)-3-amino-1-hexanol

: 230637-46-4
(S)-tert-butyl (1-hydroxyhexan-3-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h;

Reference yield:

: (3S,αS)-tert-butyl 3-(N-benzyl-N-α-methylbenzylamino)hexanoate

: 230637-46-4
(S)-tert-butyl (1-hydroxyhexan-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 2585.81 Torr

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00747

Reference yield:

: (S)-3-(benzyl((S)-1-phenylethyl)amino)hexan-1-ol

: 230637-46-4
(S)-tert-butyl (1-hydroxyhexan-3-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 2585.81 Torr

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00747