(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

Base Information

Chemical Name:(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol
CAS No.:134993-15-0
Molecular Formula:C₂₃H₃₁NO
Molecular Weight:337.505
Hs Code.:

Synonyms:(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

Chemical Property:

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Technology Process of (1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

There total 5 articles about (1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 917-64-6
methyl magnesium iodide

: 134993-14-9
(2S,3R,5S,8aR)-2,3-Diphenyl-5-propyl-hexahydro-oxazolo[3,2-a]pyridine

: 134993-15-0
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

Guidance literature:: In diethyl ether; at 0 ℃; for 2h;
DOI:10.1080/00397919108016778

Reference yield:

: 23364-44-5
(1S,2R)-2-Amino-1,2-diphenylethanol

: 134993-15-0
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) citric acid, 2.) ZnBr₂ / 1.) H₂O, a.) 0 deg C, 30 min, b.) RT, 3 h, 2.) CH₂Cl₂, 3 h

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 3 h

3: 1.) AgBF₄, 2.) Zn(BH₄)2 / 1.) THF, 0 deg C, 15 min, 2.) -78 deg C, 2 h

4: 90 percent / diethyl ether / 2 h / 0 °C

With silver tetrafluoroborate; zinc(II) tetrahydroborate; citric acid; zinc dibromide; lithium diisopropyl amide; In diethyl ether;
DOI:10.1080/00397919108016778

Reference yield:

: 134993-12-7
(2S,3R,5S,8aR)-2,3-Diphenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile

: 134993-15-0
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1,2-diphenyl-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 3 h

2: 1.) AgBF₄, 2.) Zn(BH₄)2 / 1.) THF, 0 deg C, 15 min, 2.) -78 deg C, 2 h

3: 90 percent / diethyl ether / 2 h / 0 °C

With silver tetrafluoroborate; zinc(II) tetrahydroborate; lithium diisopropyl amide; In diethyl ether;
DOI:10.1080/00397919108016778