permethyldistamycin A

Base Information

Chemical Name:permethyldistamycin A
CAS No.:75792-61-9
Molecular Formula:C₂₈H₃₉N₉O₄*ClH
Molecular Weight:602.136
Hs Code.:

Synonyms:1H-Pyrrole-2-carboxamide,N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1,2,4-trimethyl-1H-pyrrol-3-yl]-4-[[[4-(4-formylamino)-1,3,5-trimethyl-1H-pyrrol-2-yl]carbonyl]amino]-1,3,5-trimethyl-,monohydrochloride (9CI)

Suppliers and Price of permethyldistamycin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of permethyldistamycin A

Chemical Property:

PSA：181.06000
LogP:5.52910

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of permethyldistamycin A

There total 17 articles about permethyldistamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64-18-6
formic acid

: 75792-60-8
N-<5-<<(3-amino-3-iminopropyl)amino>carbonyl>-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide hydrochloride

: 75792-61-9
N-<5-<<(3-amino-3-iminopropyl)amino>carbonyl>-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-(formylamino)-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide hydrochloride

Guidance literature:: for 2h; Heating;
DOI:10.1021/jm00133a008

Reference yield:

: 7473-16-7
ethyl 4-carboxy-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-61-9
N-<5-<<(3-amino-3-iminopropyl)amino>carbonyl>-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-(formylamino)-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 13 steps

1: 100 percent / NaH / 90 °C / 10 Torr

2: 75 percent / diphenylphosphoryl azide (DPPA), Et₃N / acetonitrile / 1.5 h / 50 °C

3: 95 percent / CuCl / 5 h / 60 °C

4: H₂ / 10percent Pd/C / dioxane / 12 h

5: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

6: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

7: 100 percent / H₂ / 10percent Pd/C / dioxane; ethanol / 4 h / Heating

8: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

9: 85 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 48 h, 2.) 40 deg C, 24 h

10: 100 percent / H₂ / 30percent Pd/C / dioxane; methanol / 2 h / Heating

11: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.5 h / 0 °C

12: Et₃N / dimethylformamide / 3 h / Ambient temperature

13: 100 percent / 2 h / Heating

With diphenylphosphoranyl azide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hydride; acetic acid; triethylamine; copper(l) chloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008

Reference yield:

: 75792-41-5
ethyl 4-isocyanato-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-61-9
N-<5-<<(3-amino-3-iminopropyl)amino>carbonyl>-1,2,4-trimethylpyrrol-3-yl>-4-<<<4-(formylamino)-1,3,5-trimethylpyrrol-2-yl>carbonyl>amino>-1,3,5-trimethylpyrrole-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1: Et₃N / acetonitrile / 5 h / 50 °C

2: H₂ / 10percent Pd/C / methanol

3: 100 percent / Na / 4 h / 100 °C

5: H₂ / 10percent Pd/C / dioxane / 12 h

6: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

7: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

8: 100 percent / H₂ / 10percent Pd/C / dioxane; ethanol / 4 h / Heating

9: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

10: 85 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 48 h, 2.) 40 deg C, 24 h

11: 100 percent / H₂ / 30percent Pd/C / dioxane; methanol / 2 h / Heating

12: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.5 h / 0 °C

13: Et₃N / dimethylformamide / 3 h / Ambient temperature

14: 100 percent / 2 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008