4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one

Base Information

• Chemical Name: 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one
• CAS No.: 1358806-26-4
• Molecular Formula: C₃₀H₂₇N₇O₃S
• Molecular Weight: 565.655
• Mol file: 1358806-26-4.mol

Synonyms:4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one

Chemical Property of 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one

There total 4 articles about 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-{4-[4-(benzylideneamino)phenylamino]-6-dimethylamino-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one (1358806-24-2) + mercaptoacetic acid (68-11-1) → 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one (1358806-26-4)

Guidance literature:

In benzene; for 6h; Azeotropic water removal;

DOI:10.1016/j.ejmech.2011.11.041

Reference yield:

4-(4-chloro-6-dimethylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (1358806-20-8) → 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one (1358806-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / 1,4-dioxane / Reflux

2: piperidine / ethanol / Reflux

3: benzene / 6 h / Azeotropic water removal

With piperidine; potassium carbonate; In 1,4-dioxane; ethanol; benzene;

DOI:10.1016/j.ejmech.2011.11.041

Reference yield:

2-dimethylamino-4,6-dichloro-1,3,5-triazine (2401-64-1) → 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one (1358806-26-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 15 h / 20 - 50 °C

2: potassium carbonate / 1,4-dioxane / Reflux

3: piperidine / ethanol / Reflux

4: benzene / 6 h / Azeotropic water removal

With piperidine; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;

DOI:10.1016/j.ejmech.2011.11.041

upstream raw materials:

4-{4-[4-(benzylideneamino)phenylamino]-6-dimethylamino-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one

mercaptoacetic acid

4-(4-chloro-6-dimethylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one

4-[4-(4-aminophenylamino)-6-dimethylamino-[1,3,5]triazin-2-yloxy]-1-methyl-1H-quinolin-2-one

Downstream raw materials:

4-(4-dimethylamino-6-{4-[5-(4-ethylpiperazin-1-ylmethyl)-4-oxo-2-phenylthiazolidin-3-yl]phenylamino}-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one