2401-64-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(N,N-Diethylamino)-4,6-dichlorotriazine is used as a synthetic intermediate for the development of pharmaceuticals, leveraging its reactivity to form new compounds with potential therapeutic applications.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2-(N,N-Diethylamino)-4,6-dichlorotriazine is utilized as a key component in the synthesis of various dyes and pigments, contributing to their color and stability properties.
Used in Agricultural Chemicals:
2-(N,N-Diethylamino)-4,6-dichlorotriazine is employed as a raw material in the production of agricultural chemicals, where it plays a role in the development of effective and stable agrochemical products.
Used as a Catalyst:
2-(N,N-Diethylamino)-4,6-dichlorotriazine is used as a catalyst in various chemical reactions, enhancing the reaction rates and selectivity, which is crucial for the efficiency of chemical processes in different industries.
Used in Chemical Reactions:
Due to its ability to react with a wide range of compounds, 2-(N,N-Diethylamino)-4,6-dichlorotriazine is used in a variety of chemical reactions across the organic chemistry field, facilitating the synthesis of new compounds for diverse applications.

InChI:InChI=1/C5H6Cl2N4/c1-11(2)5-9-3(6)8-4(7)10-5/h1-2H3

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 60-29-7 diethyl ether 

Downstream Products

• 153429-75-5 SAE9 
• 1358806-24-2 4-{4-[4-(benzylideneamino)phenylamino]-6-dimethylamino-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one 
• 1358806-26-4 4-{4-dimethylamino-6-[4-(4-oxo-2-phenylthiazolidin-3-yl)phenylamino]-[1,3,5]triazin-2-yloxy}-1-methyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Novel S-triazine accommodated 5-benzylidino-4-thiazolidinones: Synthesis and in vitro biological evaluations

In order to explore various pharmacological effects associated with S-triazine accommodated 5-benzylidino-4-thiazolidinones, a series of compounds based on 5-benzylidene-2-[4-(4,6-bis-dimethylamino-[1,3,5]triazin-2-ylamino)-phenylimino]-thiazolidin-4-one

A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells

Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell line, MDA-MB-468. SM40, the most potent derivative, induced a G2/M arrest and apoptosis with a possible involvement of p53. The cytotoxicity of SM40 was also examined against the NCI 60 cell line panel and its potency was rationalized using molecular modeling. Results suggest that SM40 is a promising cytotoxic agent.

HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS

The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Glass engineering of aminotriazine-based materials with sub-ambient: T gand high kinetic stability

A challenge in glass engineering is the design of molecular glasses combining a high glass kinetic stability (GS) of the amorphous phase with a low (sub-ambient) glass transition temperature (Tg). Triazine derivatives with arylamino substituents readily form glassy phases that can show outstanding resistance to crystallization. In the present study, a series of 12 analogous compounds incorporating phenylamino and cyclohexylamino groups was synthesized, and their thermal properties and intermolecular interactions were studied. All compounds possess an excellent glass-forming ability, a low Tg ranging from 32 °C to as low as -19 °C, and a high GS. While the cyclohexyl derivatives show higher Tg, the phenyl derivatives possess a higher GS with some compounds remaining completely amorphous for over three years despite their sub-ambient Tg. X-ray diffraction, infrared spectroscopy and DFT calculations reveal that the higher volume occupancy and rotational energy barrier of cyclohexyl groups are the main factors responsible for the compounds' higher Tg values but that they also contribute to their higher propensity to crystallize. In counterpart, the planarity of phenyl groups leads to poorer packing and enhances their GS while keeping their Tg well below ambient. The formation of hydrogen bonds or competing interactions provides an additional handle to tune the Tg of the compounds. Taken together, these studies provide guidelines for the design of molecular glasses with readily tunable thermal properties in view of their functionalization. This journal is

Synthesis of nitrogen and sulfur-containing synergistic flame retardant compound and preparation method of intercalated modified hydrotalcite thereof

The invention relates to synthesis of a nitrogen and sulfur-containing synergistic flame retardant compound and a preparation method of intercalated modified hydrotalcite thereof. By means of the "structure memory effect" of hydrotalcite, the compound is introduced into the interlayer of hydrotalcite, thus significantly improving the dispersion performance of a hydrotalcite-based flame retardant and enhancing flame retardance to a polymer matrix. Based on the flame-retardant mechanism and high-efficiency flame-retardant properties peculiar to nitrogen-sulfur compounds, the compound is introduced to the interlayer of hydrotalcite by self-assembly reconstruction to prepare a novel organic-inorganic hybrid flame retardant, thus enhancing the hydrophilic properties of the hydrotalcite surface,and also further enhancing the flame-retardant properties. The prepared nitrogen and sulfur-containing synergistic flame retardant compound intercalated hydrotalcite composite flame retardant can significantly improve the flame-retardant effect after filling in the polymer matrix, and has good application value in improving the flame retardance of polyolefins. The preparation of the nitrogen-sulfur synergistic flame retardant compound is simple and practicable, the reaction conditions are easy to control, and the flame retardant efficiency is high.

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

G protein-coupled receptor 68 (GPR68) is an understudied orphan G protein-coupled receptor (GPCR). It is expressed most abundantly in the brain, potentially playing important roles in learning and memory. Pharmacological studies with GPR68 have been hinde

S - triazine derivative using the polymerization of the curable composition, the curing and molding material using them (by machine translation)

[Problem] s - triazine derivative using the same molding processability and excellent in storage stability of the polymerizable composition, such as a cured product having excellent heat resistance and productivity of the molding material. (1) Represented by the formula [a], s - triazine derivative polymer. (R1 And R2 Is independently, H, a straight chain alkyl group or branched C1 a-6 // non-substituted aryl group; R1 And R2 The ring may be bonded together to form a; R3 And R4 Is H or a straight-chain alkyl groups are independently C1 a-6/branched; and independently of the linear/branched C1 a-8 A B alkyl group, alkoxy group or halogen atom C1 a-6; n is an integer of 0 - 4 m and are independently; m and n are 2 or more A, each of the substituted benzene ring may condense with B)[Drawing] no (by machine translation)

Synthesis method and application of naphthalimides derivatives containing cyanuric chloride

The invention discloses synthesis and application of naphthalimides derivatives containing cyanuric chloride, and belongs to the field of biological organic synthesis. According to the invention, a cyanuric chloride derivative is introduced onto a naphthalimides parent, so that the drug tolerance can be effectively avoided, and an antitumour effect is improved. According to the naphthalimides derivatives containing cyanuric chloride, different cyclic amine groups are used for replacing Br at the tail end of anhydride naphthalene, and the structure-function relationship of pharmaceutical molecules is researched; cyanuric chloride is modified by different aliphatic amine, aromatic amine or alcohol, and the structure-function relationship of pharmaceutical molecules is researched; aminoethylpiperazine is taken as a bridge chain to connect the modified anhydride naphthalene with the naphthalimides derivatives through substitution reaction, and the novel naphthalimides derivatives containing cyanuric chloride is formed through synthesis and has the antitumour effect.

Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives

A series of 4-anilinoquinoline triazine derivatives were designed, synthesized and screened for in vivo antimalarial activity against a chloroquine-sensitive strain of Plasmodium berghei. The compounds were further subjected to in vitro antimalarial activity against chloroquine-resistant W2 strain of Plasmodium falciparum and β-haematin inhibition studies. All the compounds exhibited in vivo antimalarial activity better than that shown by the standard drug, chloroquine. Twelve out of fifteen compounds showed better inhibition than that of chloroquine against chloroquine-resistant W2 strain of Plasmodium falciparum. Ten compounds showed β-haematin inhibition, better than that of chloroquine, with IC50 values in the range of 18–25?μM. One compound, 3k, was found to be better than artemisinin against W2 strain of Plasmodium falciparum and also displayed the best β-haematin inhibitory activity, thereby becoming eligible to be explored as a potential lead for antimalarial chemotherapy.

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.