2401-64-1

Basic information

• Product Name: 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE
• Synonyms: 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE;SALOR-INT L118281-1EA;2,4-dichloro-6-dimethylamino-s-triazin;5-triazin-2-amine,4,6-dichloro-n,n-dimethyl-3;2,4-DICHLORO-6-(DIMETHYLAMINO)-S-TRIAZINE;2,4-Dichloro-6-(dimethylamino)-1,3,5-triazine;4,6-Dichloro-N,N-dimethyl-1,3,5-triazin-2-amine;1,3,5-Triazin-2-aMine, 4,6-dichloro-N,N-diMethyl-
• CAS NO: 2401-64-1
• Molecular Formula: C₅H₆Cl₂N₄
• Molecular Weight: 221.09
• Mol File: 2401-64-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 344.314 °C at 760 mmHg
• Flash Point: 162.036 °C
• Appearance: /
• Density: 1.473 g/cm³
• Vapor Pressure: 6.64E-05mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE(2401-64-1)
• EPA Substance Registry System: 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE(2401-64-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 2401-64-1(Hazardous Substances Data)

Usage

General Description

2-(N,N-Diethylamino)-4,6-dichlorotriazine, also known as Diethylamino-2,4,6-triazin-1-yl) sulfanylalcohol, is a chemical compound used in the synthesis of pharmaceuticals and in the production of dyes, pigments, and agricultural chemicals. It is a triazine derivative with two ethylamino groups and two chlorine atoms attached to the triazine ring. 2-(N,N-DIETHYLAMINO)-4,6-DICHLOROTRIAZINE is known for its ability to react with a wide range of organic and inorganic compounds, making it useful in a variety of chemical reactions. Additionally, it is used as a catalyst and as an intermediate in the production of various chemical products. Its versatile properties make it a valuable chemical in the field of organic chemistry and industry.

InChI:InChI=1/C5H6Cl2N4/c1-11(2)5-9-3(6)8-4(7)10-5/h1-2H3

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 60-29-7 diethyl ether 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 153429-75-5 SAE9 
• 3140-74-7 2-chloro-4,6-bis(dimethylamino)-1,3,5-triazine 

Relevant articles and documents

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A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells

Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell line, MDA-MB-468. SM40, the most potent derivative, induced a G2/M arrest and apoptosis with a possible involvement of p53. The cytotoxicity of SM40 was also examined against the NCI 60 cell line panel and its potency was rationalized using molecular modeling. Results suggest that SM40 is a promising cytotoxic agent.

Glass engineering of aminotriazine-based materials with sub-ambient: T gand high kinetic stability

A challenge in glass engineering is the design of molecular glasses combining a high glass kinetic stability (GS) of the amorphous phase with a low (sub-ambient) glass transition temperature (Tg). Triazine derivatives with arylamino substituents readily form glassy phases that can show outstanding resistance to crystallization. In the present study, a series of 12 analogous compounds incorporating phenylamino and cyclohexylamino groups was synthesized, and their thermal properties and intermolecular interactions were studied. All compounds possess an excellent glass-forming ability, a low Tg ranging from 32 °C to as low as -19 °C, and a high GS. While the cyclohexyl derivatives show higher Tg, the phenyl derivatives possess a higher GS with some compounds remaining completely amorphous for over three years despite their sub-ambient Tg. X-ray diffraction, infrared spectroscopy and DFT calculations reveal that the higher volume occupancy and rotational energy barrier of cyclohexyl groups are the main factors responsible for the compounds' higher Tg values but that they also contribute to their higher propensity to crystallize. In counterpart, the planarity of phenyl groups leads to poorer packing and enhances their GS while keeping their Tg well below ambient. The formation of hydrogen bonds or competing interactions provides an additional handle to tune the Tg of the compounds. Taken together, these studies provide guidelines for the design of molecular glasses with readily tunable thermal properties in view of their functionalization. This journal is

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

G protein-coupled receptor 68 (GPR68) is an understudied orphan G protein-coupled receptor (GPCR). It is expressed most abundantly in the brain, potentially playing important roles in learning and memory. Pharmacological studies with GPR68 have been hinde