4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine

Base Information

• Chemical Name: 4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine
• CAS No.: 2401-64-1
• Molecular Formula: C5H6Cl2N4
• Molecular Weight: 193.0339
• Hs Code.: 2933699090
• UNII: RVI31V7VBG
• DSSTox Substance ID: DTXSID30178746
• Nikkaji Number: J49.127F
• Wikidata: Q83049223
• Mol file: 2401-64-1.mol

Synonyms:4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine;2401-64-1;BRN 0146560;1,3,5-Triazin-2-amine, 4,6-dichloro-N,N-dimethyl-;RVI31V7VBG;C5H6Cl2N4;2,4-Dichloro-6-dimethylamino-s-triazine;AI3-51034;(4,6-dichloro-[1,3,5]triazin-2-yl)-dimethyl-amine;s-Triazine, 2,4-dichloro-6-dimethylamino-;2,4-Dichloro-6-(dimethylamino)-1,3,5-triazine;5-26-08-00014 (Beilstein Handbook Reference);1,3,5-Triazin-2-amine, 4,6-dichloro-N,N-dimethyl- (9CI);UNII-RVI31V7VBG;2,4-dichloro-6-dimethylamino-1,3,5-triazine;SCHEMBL1966816;DTXSID30178746;CAA40164;STL573590;AKOS012165434;SB73651;LS-155329;BB 0259501;CS-0165397;FT-0709839;E88073;4-dimethyl-amino-2,6-dichloro-1,3,5-triazine;A878057;2-(DIMETHYLAMINO)-4,6-DICHLORO-S-TRIAZINE;4,6-DICHLORO-2-(DIMETHYLAMINO)-1,3,5-TRIAZINE;4,6-DICHLORO-N,N-DIMETHYL-1,3,5-TRIAZINE-2-AMINE;4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine? (Vildagliptin Impurity pound(c)

Chemical Property of 4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine

Chemical Property:

• Vapor Pressure: 6.64E-05mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 344.314 °C at 760 mmHg
• Flash Point: 162.036 °C
• PSA: 41.91000
• Density: 1.473 g/cm³
• LogP: 1.24440
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 191.9969516
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=NC(=NC(=N1)Cl)Cl

Technology Process of 4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine

There total 7 articles about 4,6-dichloro-N,N-dimethyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + dimethyl amine (124-40-3) → 2-dimethylamino-4,6-dichloro-1,3,5-triazine (2401-64-1)

Guidance literature:

In 1,2-dimethoxyethane; water; a) -15 deg C, 2 h, b) RT, 20 h;

DOI:10.1248/cpb.45.291

Reference yield: 86.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + N,N-dimethylammonium chloride (506-59-2) → 2-dimethylamino-4,6-dichloro-1,3,5-triazine (2401-64-1)

Guidance literature:

With sodium hydroxide; In water; acetone; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2011.09.116

Reference yield: 86.0%

→ 2-dimethylamino-4,6-dichloro-1,3,5-triazine (2401-64-1)

Guidance literature:

upstream raw materials:

1,3,5-trichloro-2,4,6-triazine

dimethyl amine

diethyl ether

N,N-dimethylammonium chloride

Downstream raw materials:

4-[4-(4-aminophenylamino)-6-dimethylamino-[1,3,5]triazin-2-yloxy]-1-methyl-1H-quinolin-2-one

4-(4-{4-[2-(2,3-dihydroxyphenyl)-5-(4-ethylpiperazin-1-ylmethyl)-4-oxothiazolidin-3-yl]phenylamino}-6-dimethylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one

4-(4-{4-[2-(2,4-dihydroxyphenyl)-5-(4-ethylpiperazin-1-ylmethyl)-4-oxothiazolidin-3-yl]phenylamino}-6-dimethylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one

4-(4-{4-[2-(3,4-dimethoxyphenyl)-5-(4-ethylpiperazin-1-ylmethyl)-4-oxothiazolidin-3-yl]phenylamino}-6-dimethylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one