Chemical Property of CID 657365
Chemical Property:
- Appearance/Colour:White crystalline powder
- Melting Point:168-172 °C
- Refractive Index:1.5800 (estimate)
- Boiling Point:343.7 °C at 760 mmHg
- Flash Point:101.5 °C
- PSA：12.47000
- Density:1.024 g/cm3
- LogP:4.15620
- Storage Temp.:Desiccate at RT
- Sensitive.:Light Sensitive
- Solubility.:Very soluble in water, freely soluble in alcohol.
- Water Solubility.:1000 g/L
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:6
- Exact Mass:291.1389920
- Heavy Atom Count:20
- Complexity:211
- Purity/Quality:
-
99% *data from raw suppliers
Diphenhydramine hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn,T,F
- Statements:
22-39/23/24/25-23/24/25-11
- Safety Statements:
36-45-36/37-16-7-24/25
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:[H+].CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.[Cl-]
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Description
Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent. Diphenhydramine is most commonly used as a first-generation antihistamine and is globally marketed in various brand formulations (Benadryl?, Unisom?, Tylenol?, Zzzquil?). It competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Diphenhydramine exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities.
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Uses
Diphenhydramine is a H1-histamine receptor antagonist with anticholinergic (drying) and sedative side effects. It is categorized as an antihistaminic; sedative, hypnotic, treatment of allergic. It is used to treat allergy and cold symptoms such as sneezing, runny nose, watery eyes, urticaria (hives), skin rash, and pruritus (itchy skin).
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Therapeutic Function
Antihistaminic
