GEA 857

Base Information

• Chemical Name: GEA 857
• CAS No.: 120493-42-7
• Molecular Formula: C₁₅H₂₂ClNO₂
• Molecular Weight: 283.798
• Mol file: 120493-42-7.mol

Synonyms:GEA 857

Chemical Property of GEA 857

Chemical Property:

• Vapor Pressure: 2.2E-05mmHg at 25°C
• Boiling Point: 360.6°Cat760mmHg
• Flash Point: 171.9°C
• PSA: 52.32000
• Density: 1.101g/cm³
• LogP: 3.88790

Purity/Quality:

GEA 857 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GEA 857

There total 3 articles about GEA 857 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-2-methyl-2-propyl 2[(N-trifluoroacetyl)amino]-3-methyl-butanoate → 2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate (66171-66-2,120493-42-7)

Guidance literature:

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate (66171-66-2,120493-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) Mg, Et₂O, (ii) /BRN= 635680/

2: (i) PhNMe₂, CH₂Cl₂, (ii) aq. NaN₃, MeOH, (iii) H₂, Pd-C

DOI:10.1021/jm00203a008

Reference yield:

2-bromo-3-methyl-butyryl bromide (26464-05-1) + 1-(4-chlorophenyl)-2-methyl-2-propanol (5468-97-3) → 2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate (66171-66-2,120493-42-7)

Guidance literature:

Multistep reaction; (i) PhNMe₂, CH₂Cl₂, (ii) aq. NaN₃, MeOH, (iii) H₂, Pd-C;

DOI:10.1021/jm00203a008

upstream raw materials:

2-bromo-3-methyl-butyryl bromide

1-(4-chlorophenyl)-2-methyl-2-propanol

1-Chloro-4-(chloromethyl)benzene