<1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone

Base Information

• Chemical Name: <1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone
• CAS No.: 116996-49-7
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37

Synonyms:<1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone

Chemical Property of <1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone

Chemical Property:

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Technology Process of <1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone

There total 5 articles about <1S-<1α(R^*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone (90719-30-5) + buta-1,3-diene (106-99-0,130983-70-9,29406-96-0,9003-17-2) → (S)-4-Benzyl-3-((1R,6S)-6-methyl-cyclohex-3-enecarbonyl)-oxazolidin-2-one (116996-49-7) + <1S-<1α(R*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone (116996-49-7)

Guidance literature:

With diethylaluminium chloride; In dichloromethane; toluene; at -10 - -7 ℃; for 16h;

DOI:10.1021/ja00164a024

Reference yield: 56.0%

(4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone (90719-30-5) + buta-1,3-diene (106-99-0,130983-70-9,29406-96-0,9003-17-2) → (S)-4-Benzyl-3-((1R,6S)-6-methyl-cyclohex-3-enecarbonyl)-oxazolidin-2-one (116996-49-7) + <1S-<1α(R*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone (116996-49-7)

Guidance literature:

With diethylaluminium chloride; In dichloromethane; toluene; at -10 - -7 ℃; for 16h;

DOI:10.1021/ja00164a024

Reference yield:

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) → <1S-<1α(R*),6β>>-3-<(6-methyl-3-cyclohexen-1-yl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone (116996-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi

2: galvinoxyl; Et₂AlCl / CH₂Cl₂ / -15 - -10 °C

With n-butyllithium; 2,6-di-tert-butyl-α-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadien-1-ylidene)-p-tolyloxyl; diethylaluminium chloride; In dichloromethane; 1: Acylation / 2: Cycloaddition;

DOI:10.1016/S0040-4020(00)00219-2

upstream raw materials:

(4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone

buta-1,3-diene

(S)-4-Benzyl-2-oxazolidinone

Downstream raw materials:

(1S,6S)-(+)-6-Methyl-3-cyclohexenecarboxylic Acid

5r-Methyl-4c-methoxycarbonylcyclohex-1-en

(1R,6S)-6-methyl-3-cyclohexenemethanol

((1S,6S)-6-Methyl-cyclohex-3-enyl)-acetonitrile

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