6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

Base Information

Chemical Name:6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester
CAS No.:108947-99-5
Molecular Formula:C₂₀H₂₂ClN₅O₂
Molecular Weight:399.88
Hs Code.:

Synonyms:6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

Suppliers and Price of 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

Chemical Property:

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Technology Process of 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

There total 1 articles about 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.7%

: 18144-47-3
tert-butyl 4-aminobenzoate

: 18917-75-4
2,4-diamino-5-chloroquinazoline-6-carbonitrile

: 108947-99-5
6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

Guidance literature:: With hydrogen; nickel; In acetic acid; Ambient temperature;
DOI:10.1021/jm00391a042

Reference yield: 93.0%

: 108947-99-5
6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

: 57343-54-1
6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline

Guidance literature:: With trifluoroacetic acid; In chloroform; for 3h; Ambient temperature;
DOI:10.1021/jm00391a042

Reference yield:

: 108947-99-5
6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester

: 20242-62-0
5-chloro-5,8-dideazaaminopterin

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CF₃COOH / CHCl₃ / 3 h / Ambient temperature

2: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, 65 deg C, 30 min, 2.) DMF, 65 deg C, 18 h

3: 66 percent / CF₃COOH / 1 h / Ambient temperature

With diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In chloroform;
DOI:10.1021/jm00391a042