57343-54-1

Basic information

• Product Name: Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]-
• CAS NO: 57343-54-1
• Molecular Formula: C16H14ClN5O2
• Molecular Weight: 343.772
• Mol File: 57343-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]-(57343-54-1)
• EPA Substance Registry System: Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]-(57343-54-1)

Safety Data

• Hazardous Substances Data: 57343-54-1(Hazardous Substances Data)

Upstream product

• 108947-99-5 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester 
• 18917-75-4 2,4-diamino-5-chloroquinazoline-6-carbonitrile 
• 18144-47-3 tert-butyl 4-aminobenzoate 

Downstream Products

• 120296-61-9 6-<methyl>-5-chloro-2,4-diaminoquinazoline 
• 120296-49-3 N^α-(5-chloro-5,8-dideazapteroyl)-L-ornithine 
• 120296-60-8 5-Chloro-10-(trifluoroacetyl)-5,8-dideazapteroic acid 
• 120296-51-7 N^α-(4-Amino-4-deoxy-5-chloro-5,8-dideazapteroyl)-L-ornithine 
• 74671-08-2 5-Chloro-5,8-dideazafolic Acid 
• 120296-64-2 N^δ-(tert-Butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazapteroyl)-L-ornithine 
• 120296-67-5 Di-tert-butyl-5-chloro-5,8-dideazafolate 
• 120296-65-3 N^α-(4-Amino-4-deoxy-5-chloro-5,8-dideazapteroyl)-N^δ-(tert-butyloxycarbonyl)-L-ornithine 
• 120296-63-1 (S)-5-tert-Butoxycarbonylamino-2-{4-[(2,4-diamino-5-chloro-quinazolin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-pentanoic acid 
• 120296-62-0 (S)-2-{4-[(2-Amino-5-chloro-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-5-tert-butoxycarbonylamino-pentanoic acid 
• 120296-66-4 di-tert-butyl-5-chloro-N¹⁰-(trifluoroacetyl)-5,8-dideazafolate 
• 20242-62-0 5-chloro-5,8-dideazaaminopterin 
• 120296-59-5 5-Chloro-5,8-dideazapteroic acid 
• 108948-00-1 (S)-2-{4-[(2,4-Diamino-5-chloro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid di-tert-butyl ester 

Relevant articles and documents

Synthesis of 5-chloro-5,8-dideaza analogues of folic acid and aminopterin targeted for colon adenocarcinoma

Several classical quinazoline analogues of folic acid bearing chloro or methyl substituents at position 5 were evaluated as inhibitors of the growth of four human gastrointestinal adenocarcinoma cell lines in vitro. The preparation of two of these, 5-chlo