N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

Base Information

Chemical Name:N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide
CAS No.:1130021-20-3
Molecular Formula:C₂₈H₃₄N₂O₄
Molecular Weight:462.589
Hs Code.:

Synonyms:N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

Chemical Property:

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Technology Process of N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

There total 4 articles about N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1272675-72-5
N-[(6β,14β-epoxy-17-isobutyl-3-methoxymorphinan-6α-yl)methyl]-4-methoxybenzamide

: 1130021-20-3
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: With 1-thiopropane; potassium tert-butylate; In N,N-dimethyl-formamide; at 150 ℃;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-77-4
C₂₂H₂₈N₄O₂

: 1130021-20-3
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; camphor-10-sulfonic acid; hydrogen / methanol / 96 h / 20 °C

2: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

3: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

With platinum(IV) oxide; 1-thiopropane; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1130020-76-6
(6β,14β-epoxy-17-isobutyl-3-methoxymorphinan-6α-yl)methanamine

: 1130021-20-3
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

2: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

With 1-thiopropane; potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035