N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

Base Information

Chemical Name:N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride
CAS No.:1130020-80-2
Molecular Formula:C₂₈H₃₄N₂O₄*ClH
Molecular Weight:499.05
Hs Code.:

Synonyms:N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

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Chemical Property of N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

Chemical Property:

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Technology Process of N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

There total 5 articles about N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1130021-20-3
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide

: 1130020-80-2
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-77-4
C₂₂H₂₈N₄O₂

: 1130020-80-2
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: platinum(IV) oxide; camphor-10-sulfonic acid; hydrogen / methanol / 96 h / 20 °C

2: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

3: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

4: hydrogenchloride / methanol

With hydrogenchloride; platinum(IV) oxide; 1-thiopropane; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1130020-76-6
(6β,14β-epoxy-17-isobutyl-3-methoxymorphinan-6α-yl)methanamine

: 1130020-80-2
N-[(6β,14β-epoxy-3-hydroxy-17-isobutylmorphinan-6α-yl)methyl]-4-hydroxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

2: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

3: hydrogenchloride / methanol

With hydrogenchloride; 1-thiopropane; potassium tert-butylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035