(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

Base Information

Chemical Name:(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine
CAS No.:155591-07-4
Molecular Formula:C₃₀H₃₂N₂O₃S
Molecular Weight:500.662
Hs Code.:

(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benz<e>indol-8-amine

Synonyms:(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

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Technology Process of (8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

There total 1 articles about (8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 79-03-8
propionyl chloride

: (8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine hydrochloride

: 155591-07-4
(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/jhet.5570310123

Reference yield: 93.0%

: 155591-07-4
(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

: 155591-09-6
(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/jhet.5570310123

Reference yield:

: 155591-07-4
(8S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propionyl-N-<(S)-α-methylbenzyl>-3H-benzindol-8-amine

: (S)-3-p-toluenesulfonyl-6,7,8,9-tetrahydro-N-propyl-3H-benzindol-8-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / lithium aluminum hydride, aluminum chloride / tetrahydrofuran / 0 - 20 °C

2: 1.) 1-chloroethyl chloroformate, 2.) methanol / 1.) 130 deg C, 24 h, 2.) 80 deg C, 1 h

With methanol; lithium aluminium tetrahydride; aluminium trichloride; carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran;
DOI:10.1002/jhet.5570310123