methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

Base Information

Chemical Name:methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate
CAS No.:892491-69-9
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

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Chemical Property of methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

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Technology Process of methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

There total 6 articles about methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5781-53-3
monomethyl oxalyl chloride

: 892491-68-8
trans-[4-(4-aminophenyl)cyclohexyl]acetic acid methyl ester

: 892491-69-9
methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 64h;

Reference yield:

: 105640-07-1
4-(4-hydroxyphenyl)cyclohexan-1-one

: 892491-69-9
methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 12 - 20 °C

1.2: 17 h / 8 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 °C / 1500.15 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

5.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

5.2: pH 9

6.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

With pyridine; hydrogenchloride; methanol; water; hydrogen; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane;

Reference yield:

: 701232-66-8
[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester

: 892491-69-9
methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 °C / 1500.15 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

4.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

4.2: pH 9

5.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

With pyridine; hydrogenchloride; methanol; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane;