4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole

Base Information

• Chemical Name: 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole
• CAS No.: 360062-30-2
• Molecular Formula: C₁₇H₁₈N₄O₂
• Molecular Weight: 310.356
• Mol file: 360062-30-2.mol

Synonyms:4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole

Chemical Property of 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole

There total 5 articles about 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 3-amino-4-cyano-5-methyl-2-methoxycarbonyl-1-phenylpyrrole (352554-07-5) → 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole (360062-30-2)

Guidance literature:

In toluene; for 7h; Heating;

DOI:10.1023/A:1017566212124

Reference yield:

α-cyano-β-dimethylaminocrotonamide (62321-92-0) → 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole (360062-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / POCl₃ / acetonitrile / 2 h / Heating

2: 40 percent / K₂CO₃ / acetone / Heating

3: 64 percent / toluene / 7 h / Heating

With potassium carbonate; trichlorophosphate; In acetone; toluene; acetonitrile; 3: Torp-Ziegler cyclization;

DOI:10.1023/A:1017566212124

Reference yield:

α-Cyano-β-N-phenylaminocrotonamide (91255-14-0) → 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole (360062-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / POCl₃ / acetonitrile / 2 h / Heating

2: 40 percent / K₂CO₃ / acetone / Heating

3: 64 percent / toluene / 7 h / Heating

With potassium carbonate; trichlorophosphate; In acetone; toluene; acetonitrile; 2: Torp-Ziegler cyclization;

DOI:10.1023/A:1017566212124

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

3-amino-4-cyano-5-methyl-2-methoxycarbonyl-1-phenylpyrrole

α-cyano-β-dimethylaminocrotonamide

(1-phenylamino)ethylidene-propanedinitrile