(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

Base Information

Chemical Name:(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate
CAS No.:1361293-49-3
Molecular Formula:C₂₂H₂₄Cl₂N₂O₄
Molecular Weight:451.35
Hs Code.:

Synonyms:(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

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Chemical Property of (S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

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Technology Process of (S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

There total 1 articles about (S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 87219-29-2
benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate

: 1361293-49-3
(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

Guidance literature:: at 100 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1361293-49-3
(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

: 1361293-84-6
(S)-tert-butyl 4-(biphenyl-3-yl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-2-((methoxymethoxy)methyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trimethylsilyl iodide / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.1: methanol / 50 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

5.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

6.2: 20 °C

7.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.42 h / 20 - 150 °C / Inert atmosphere; Microwave irradiation

With trimethylsilyl iodide; sodium; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene; acetonitrile;

Reference yield:

: 1361293-49-3
(S)-benzyl 4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylcarbamate

: 1361293-94-8
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-2-((methoxymethoxy)methyl)-4-(4-methoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trimethylsilyl iodide / acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2.1: methanol / 50 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

5.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

6.2: 20 °C

7.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

8.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With trimethylsilyl iodide; sodium; sodium hydride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;