3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

Base Information

Chemical Name:3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester
CAS No.:691012-84-7
Molecular Formula:C₁₇H₂₇ClO₅Si
Molecular Weight:374.937
Hs Code.:

3-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

Synonyms:3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

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Chemical Property of 3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

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Technology Process of 3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

There total 2 articles about 3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: C₂₂H₃₇ClO₅Si

: 691012-84-7
3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

Guidance literature:: C₂₂H₃₇ClO₅Si; With ozone; In dichloromethane; at -78 ℃; for 2h;

With dimethylsulfide; In dichloromethane; at 20 ℃; for 3h;

With methanol; pyridinium p-toluenesulfonate; for 2h; Further stages.;
DOI:10.1021/ja076671f

Reference yield:

: 67-56-1
methanol

: 76397-53-0
3-acetylthiazolidine-2-thione

: 691012-74-5
3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-benzaldehyde

: 691012-84-7
3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

: 3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-3-hydroxy-propionic acid methyl ester

Guidance literature:: 3-acetylthiazolidine-2-thione; 3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-benzaldehyde; With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; chiral diamine; In dichloromethane; at -95 ℃; for 10h;

methanol; With potassium carbonate; at 20 ℃; for 0.333333h; Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2004.02.020