1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

Base Information

Chemical Name:1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone
CAS No.:1026314-83-9
Molecular Formula:C₃₆H₄₃NO₄SSi
Molecular Weight:613.893
Hs Code.:

Synonyms:1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

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Chemical Property of 1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

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Technology Process of 1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

There total 4 articles about 1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-34-2,92680-80-3
-butyl vinyl ether

: 185416-87-9
Trifluoro-methanesulfonic acid 4-{6-(tert-butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl ester

: 1026314-83-9
1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

Guidance literature:: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 19h;
DOI:10.1021/jm9606352

Reference yield:

: 84449-90-1
Raloxifen

: 1026314-83-9
1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h

2: 88 percent / Et₃N / 1,2-dichloro-ethane / Ambient temperature

3: Et₃N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 19 h / 80 °C

With dmap; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9606352

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1026314-83-9
1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h

2: 88 percent / Et₃N / 1,2-dichloro-ethane / Ambient temperature

3: Et₃N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 19 h / 80 °C

With dmap; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9606352