Technology Process of methyl 2-{[(2,5-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate
There total 5 articles about methyl 2-{[(2,5-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / H2 / Pd/C / methanol; H2O / 2.5 h / 60 °C / 77572.2 Torr
2: pyridine / CH2Cl2 / -20 - 20 °C
3: 54.06 g / Cs2CO3; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C
4: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C
5: pyridine / 20 °C
With
pyridine; hydrogenchloride; palladium diacetate; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water;
3: Buchwald reaction;
DOI:10.1021/jm0601001
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 54.06 g / Cs2CO3; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C
2: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C
3: pyridine / 20 °C
With
hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; pyridine;
1: Buchwald reaction;
DOI:10.1021/jm0601001
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C
2: pyridine / 20 °C
With
hydrogenchloride;
In
tetrahydrofuran; pyridine;
DOI:10.1021/jm0601001
