{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester
CAS No.:370102-95-7
Molecular Formula:C₃₀H₄₄N₄O₅Si
Molecular Weight:568.789
Hs Code.:

Synonyms:{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

There total 5 articles about {(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210547-98-1
{(S)-2-Benzyloxyamino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

: 370102-95-7
{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; at 56 ℃; for 2h; under 735.5 Torr;
DOI:10.1021/jo980063o

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 370102-95-7
{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / EDC-HCl

2: 98 percent / triphenylphosphine, TEA, CCl₄ / acetonitrile

3: 100 percent / LiOH / H₂O; tetrahydrofuran / 3 h / Ambient temperature

4: 91 percent / HOAt, DMAP, EDC-HCl / dimethylformamide / 6 h / Ambient temperature

5: 45 mg / H₂ / 10percent Pd-C / 2 h / 56 °C / 735.5 Torr

With tetrachloromethane; dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; TEA; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo980063o

Reference yield:

: 26048-92-0
L-tert-butyl {1-[(benzyloxy)amino]-3-hydroxy-1-oxopropan-2-yl}carbamate

: 370102-95-7
{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / triphenylphosphine, TEA, CCl₄ / acetonitrile

2: 100 percent / LiOH / H₂O; tetrahydrofuran / 3 h / Ambient temperature

3: 91 percent / HOAt, DMAP, EDC-HCl / dimethylformamide / 6 h / Ambient temperature

4: 45 mg / H₂ / 10percent Pd-C / 2 h / 56 °C / 735.5 Torr

With tetrachloromethane; dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; TEA; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo980063o