N-BOC-L-SER-NHOBN

Base Information

• Chemical Name: N-BOC-L-SER-NHOBN
• CAS No.: 26048-92-0
• Molecular Formula: C15H22 N2 O5
• Molecular Weight: 310.3456
• Mol file: 26048-92-0.mol

Synonyms:Carbamicacid, [(1S)-1-(hydroxymethyl)-2-oxo-2-[(phenylmethoxy)amino]ethyl]-,1,1-dimethylethyl ester (9CI); Carbamic acid,[1-(hydroxymethyl)-2-oxo-2-[(phenylmethoxy)amino]ethyl]-, 1,1-dimethylethylester, (S)-; Carbamic acid, [1-[(benzyloxy)carbamoyl]-2-hydroxyethyl]-,tert-butyl ester, L- (8CI); NSC 337388

Chemical Property of N-BOC-L-SER-NHOBN

Chemical Property:

• Appearance/Colour: White Solid
• PSA: 96.89000
• Density: 1.192 g/cm³
• LogP: 1.90180
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

O-Benzyl-α-N-tert-Boc-L-serinehydroxamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-L-SER-NHOBN

There total 2 articles about N-BOC-L-SER-NHOBN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) + O-benzylhydoxylamine hydrochloride (2687-43-6) → L-tert-butyl {1-[(benzyloxy)amino]-3-hydroxy-1-oxopropan-2-yl}carbamate (26048-92-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; water; for 3h; pH 4.5;

DOI:10.1021/jo01291a007

Reference yield: 68.0%

N-tert-butyloxycarbonyl-L-serine methyl ester (2766-43-0) + O-benzylhydoxylamine hydrochloride (2687-43-6) → L-tert-butyl {1-[(benzyloxy)amino]-3-hydroxy-1-oxopropan-2-yl}carbamate (26048-92-0)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo0509713

Reference yield: 98.0%

L-tert-butyl {1-[(benzyloxy)amino]-3-hydroxy-1-oxopropan-2-yl}carbamate (26048-92-0) → L-serine O-benzylhydroxamate N-hydrochloride (26191-98-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;

DOI:10.1021/jo00207a045

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)serine

O-benzylhydoxylamine hydrochloride

N-tert-butyloxycarbonyl-L-serine methyl ester

Downstream raw materials:

O⁴-Benzyl-N-(tert-butyloxycarbonyl)neoenactin A

L-serine O-benzylhydroxamate N-hydrochloride

(S)-3-Benzyloxyamino-2-tert-butoxycarbonylamino-propionic acid

{(S)-2-Amino-1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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