(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate
CAS No.:1620056-35-0
Molecular Formula:C₃₃H₂₇F₃N₄O₅
Molecular Weight:616.596
Hs Code.:

Synonyms:(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Suppliers and Price of (S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

There total 9 articles about (S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874219-34-8
(3-carbamoyl-4-fluorophenyl)boronic acid

: 1620056-34-9
(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

: 1620056-35-0
(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

: 1620056-36-1
C₃₃H₂₉F₃N₄O₆

Guidance literature:: With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium hydrogencarbonate; In 1,4-dioxane; water; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 85-44-9
phthalic anhydride

: 1620056-35-0
(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

: 1620056-36-1
C₃₃H₂₉F₃N₄O₆

Guidance literature:: Multi-step reaction with 7 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

7: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation

With hydrogenchloride; selenium(IV) oxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium acetate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; copper(II) sulfate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1620056-31-6
3-bromo-5-(1,3-dioxoisoindolin-2-yl)picolinaldehyde

: 1620056-35-0
(S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

: 1620056-36-1
C₃₃H₂₉F₃N₄O₆

Guidance literature:: Multi-step reaction with 5 steps

1: copper(II) sulfate / dichloromethane / 2 h / 20 °C

2: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

4: triethylamine / dichloromethane / 0 °C

5: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 150 °C / Microwave irradiation

With hydrogenchloride; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; copper(II) sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;