4-cyanobenzoyl isocyanate

Base Information

• Chemical Name: 4-cyanobenzoyl isocyanate
• CAS No.: 30764-11-5
• Molecular Formula: C₉H₄N₂O₂
• Molecular Weight: 172.143
• Mol file: 30764-11-5.mol

Synonyms:4-cyanobenzoyl isocyanate

Chemical Property of 4-cyanobenzoyl isocyanate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-cyanobenzoyl isocyanate

There total 2 articles about 4-cyanobenzoyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanobenzoyl chlorIde (6068-72-0) → 4-cyanobenzoyl isocyanate (30764-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. NH₄OH / ethyl acetate / 0.17 h

2: CH₂Cl₂ / Heating

With ammonium hydroxide; In dichloromethane; ethyl acetate;

DOI:10.1021/jm00109a015

Reference yield:

oxalyl dichloride (79-37-8) + 4-cyanobenzamide (3034-34-2) → 4-cyanobenzoyl isocyanate (30764-11-5)

Guidance literature:

In dichloromethane; Heating;

DOI:10.1021/jm00109a015

Reference yield: 90.0%

4-cyanobenzoyl isocyanate (30764-11-5) + (6R)-3'-aminotetramisole (41774-03-2,43081-63-6) → 1-(4-Cyano-benzoyl)-3-[(S)-3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-urea (132981-03-4)

Guidance literature:

In acetonitrile; at 70 ℃;

DOI:10.1021/jm00109a015

upstream raw materials:

oxalyl dichloride

4-cyanobenzamide

4-cyanobenzoyl chlorIde

Downstream raw materials:

1-(4-Cyano-benzoyl)-3-[(S)-3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-urea