(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Chemical Name:(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol
CAS No.:1376607-09-8
Molecular Formula:C₂₃H₃₇N₅O₃
Molecular Weight:431.578
Hs Code.:

Synonyms:(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Chemical Property of (3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Technology Process of (3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

There total 10 articles about (3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-18-9
(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

: 1376607-09-8
(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: (3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol; With boron tribromide; In dichloromethane; at -70 - 20 ℃;

With hydrogenchloride; methanol; In 1,4-dioxane; dichloromethane;

With ammonia; In methanol; pH=7;

Reference yield:

: 1376514-13-4
ethyl 2-(4-cyano-2-methoxybenzyl)-3-oxobutanoate

: 1376607-09-8
(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 16 h / 65 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

3.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

4.1: pyridine; water; acetic acid; sodium phosphinate hydrate / Raney nickel / 16 h / 45 °C

5.1: acetic acid / dichloromethane / 20 °C / Molecular sieve

5.2: 3 h / 0 °C

6.1: boron tribromide / dichloromethane / -70 - 20 °C

6.3: pH 7

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; sodium phosphinate hydrate; water; boron tribromide; acetic acid; trifluoroacetic acid; Raney nickel; In tetrahydrofuran; methanol; propyl cyanide; dichloromethane;

Reference yield:

: 1376514-14-5
4-[(2-amino-4-hydroxy-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzonitrile

: 1376607-09-8
(3S)-3-{[2-amino-5-(4-{[(2-hydroxyethyl)(methyl)amino]methyl}-2-methoxybenzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

2.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

3.1: pyridine; water; acetic acid; sodium phosphinate hydrate / Raney nickel / 16 h / 45 °C

4.1: acetic acid / dichloromethane / 20 °C / Molecular sieve

4.2: 3 h / 0 °C

5.1: boron tribromide / dichloromethane / -70 - 20 °C

5.3: pH 7

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; sodium phosphinate hydrate; water; boron tribromide; acetic acid; trifluoroacetic acid; Raney nickel; In tetrahydrofuran; propyl cyanide; dichloromethane;