(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Chemical Name:(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol
CAS No.:1376514-18-9
Molecular Formula:C₂₄H₃₉N₅O₃
Molecular Weight:445.605
Hs Code.:

Synonyms:(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Chemical Property of (3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

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Technology Process of (3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

There total 10 articles about (3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38256-93-8
N-methyl-N-(2-methoxyethyl)amine

: 1376514-17-8
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzaldehyde

: 1376514-18-9
(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 0 ℃; for 3h; Molecular sieve;

Reference yield:

: 104436-60-4
4-bromomethyl-3-methoxybenzonitrile

: 1376514-18-9
(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: trichlorophosphate / 16 h / 100 °C

3.2: 1 h / 50 °C / pH 7

4.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

5.1: pyridine; acetic acid; sodium hypophosphite monohydrate / Raney nickel / water / 16 h / 45 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 °C / Molecular sieve

With pyridine; sodium hypophosphite monohydrate; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trichlorophosphate; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

Reference yield:

: 1376514-13-4
ethyl 2-(4-cyano-2-methoxybenzyl)-3-oxobutanoate

: 1376514-18-9
(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 16 h / 65 °C

2.1: trichlorophosphate / 16 h / 100 °C

2.2: 1 h / 50 °C / pH 7

3.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

4.1: pyridine; acetic acid; sodium hypophosphite monohydrate / Raney nickel / water / 16 h / 45 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 °C / Molecular sieve

With pyridine; sodium hypophosphite monohydrate; sodium tris(acetoxy)borohydride; acetic acid; trichlorophosphate; Raney nickel; In 1,4-dioxane; methanol; dichloromethane; water;