2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester

Base Information

• Chemical Name: 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester
• CAS No.: 1026295-27-1
• Molecular Formula: C₃₉H₃₅NO₇
• Molecular Weight: 629.709
• Mol file: 1026295-27-1.mol

Synonyms:2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester

Chemical Property of 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester

There total 3 articles about 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid (1027381-95-8) → 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester (1026295-27-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm020018f

Reference yield:

Pyridine-2,3-dicarboxylic anhydride (699-98-9) → 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester (1026295-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -72 °C

1.2: tetrahydrofuran; hexane / 1.5 h / -72 °C

2.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

Reference yield:

3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester (158980-57-5) → 2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid benzyl ester (1026295-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -72 °C

1.2: tetrahydrofuran; hexane / 1.5 h / -72 °C

2.1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

upstream raw materials:

benzyl bromide

2-(2,6-bis-benzyloxy-4-tert-butoxycarbonyl-benzoyl)-nicotinic acid

Pyridine-2,3-dicarboxylic anhydride

3,5-dibenzyloxy-4-bromobenzoic acid tert-butyl ester

Downstream raw materials:

2-(2,6-bis-benzyloxy-4-carboxy-benzoyl)-nicotinic acid benzyl ester