3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine

Base Information

• Chemical Name: 3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine
• CAS No.: 108310-93-6
• Molecular Formula: C₂₂H₂₃N₅O₉
• Molecular Weight: 501.453
• Mol file: 108310-93-6.mol

Synonyms:3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine

Chemical Property of 3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine

There total 1 articles about 3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate (108310-92-5) → 3',5'-di-O-acetyl-2'-deoxy-O6-[2-(4-nitrophenyl)ethyl]xanthosine (108310-93-6)

Guidance literature:

With acetic acid; sodium nitrite;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

Reference yield: 99.0%

3',5'-di-O-acetyl-2'-deoxy-O6-[2-(4-nitrophenyl)ethyl]xanthosine (108310-93-6) → 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-3,9-dihydro-purin-2-one (108310-94-7)

Guidance literature:

With ammonia; In methanol; water;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

Reference yield: 93.0%

2-(4-nitrophenyl)ethyl iodide (20264-96-4) + 3',5'-di-O-acetyl-2'-deoxy-O6-[2-(4-nitrophenyl)ethyl]xanthosine (108310-93-6) → 3',5'-di-O-acetyl-2'-deoxy-O2,O6-bis-[2-(4-nitrophenyl)ethyl]xanthosine (292050-44-3)

Guidance literature:

3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine; With silver carbonate; In benzene; for 1h; Heating;

2-(4-nitrophenyl)ethyl iodide; In benzene; at 50 ℃; for 15h;

DOI:10.1002/1522-2675(20000705)83:7<1517::AID-HLCA1517>3.0.CO;2-S

upstream raw materials:

2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

Downstream raw materials:

3',5'-di-O-acetyl-2'-deoxy-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-3,9-dihydro-purin-2-one

2'-deoxy-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine

9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-3,9-dihydro-purin-2-one