292050-44-3

Upstream product

• 20264-96-4 2-(4-nitrophenyl)ethyl iodide 
• 108310-93-6 3',5'-di-O-acetyl-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]xanthosine 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 108310-92-5 2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate 

Downstream Products

• 123107-74-4 2'-deoxy-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine 
• 292050-45-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine 
• 292050-43-2 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O²,O⁶-bis-[2-(4-nitrophenyl)ethyl]xanthosine 3'-(2-cyanoethyl diisopropylphosphoramidite) 

Relevant academic research and scientific papers

Redesigned tetrads with altered hydrogen bonding patterns enable programming of quadruplex topologies

Guanosine analogs assemble to unusual nucleobase tetrads, restricting possible conformations of four-stranded DNAs. The Royal Society of Chemistry.

Synthesis and characterization of oligonucleotides containing 2'- deoxyxanthosine using phosphoramidite chemistry

Oligodeoxynucleotides containing 2'-deoxyxanthosine (X(d)) were synthesized in good yield from a O2,O6-bis[2-(4-nitrophenyl)ethyl](NPE)- protected phosphoramidite of X(d). Attempts to synthesize a O6-monoNPE- protected phosphoramidite resulted in formation of a major by-product. The NPE protecting groups were removed by treatment with oximate ion after, other protecting groups were removed with aqueous NH4OH solution. The composition of the synthetic oligonucleotides was verified by enzymatic degradation and MALDI-TOF mass spectrometry. The efficacy of this procedure allowed isolation of oligodeoxynucleotides containing multiple X(d) residues.