(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

Base Information

Chemical Name:(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone
CAS No.:1225209-76-6
Molecular Formula:C₃₁H₂₉ClN₂O₅
Molecular Weight:545.035
Hs Code.:

Synonyms:(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

There total 7 articles about (2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 13993-61-8
1.1,2,3,4-tetrahydro-1,5-naphthyridine

: 2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoic acid

: 1225209-76-6
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

Guidance literature:: 2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzoic acid; With methanesulfonyl chloride; triethylamine; In N,N-dimethyl acetamide; at -15 ℃;

1.1,2,3,4-tetrahydro-1,5-naphthyridine; In N,N-dimethyl acetamide; at 0 ℃;

Reference yield:

: 52009-53-7
2-chloro-3,4-dimethoxy-benzoic acid

: 1225209-76-6
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 3.5 h / 0 - 20 °C

1.2: Cooling with ice

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 70 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.33 h / 70 °C

4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl acetamide / -15 °C

4.2: 0 °C

With water; boron tribromide; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 87932-50-1
2-chloro-3,4-dihydroxybenzoic acid

: 1225209-76-6
(2-chloro-3,4-bis((4-methoxybenzyl)oxy)phenyl) (3,4-dihydro-1,5-naphthyridin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 70 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.33 h / 70 °C

3.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl acetamide / -15 °C

3.2: 0 °C

With water; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;