6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

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Chemical Name:6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester
CAS No.:483340-22-3
Molecular Formula:C₂₃H₂₂BrNO₄S
Molecular Weight:488.402
Hs Code.:

Synonyms:6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

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Chemical Property of 6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

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Technology Process of 6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

There total 2 articles about 6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 91618-40-5
6α-bromo-6β-(1-hydroxyethyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

: 483340-22-3
6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

Guidance literature:: With dipyridinium dichromate; molecular sieve; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/S0014-827X(02)01261-2

Reference yield:

: 75527-84-3
diphenylmethyl 6,6-dibromopenicillanate

: 483340-22-3
6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: MeMgBr / tetrahydrofuran; diethyl ether / 0.33 h / -78 °C

1.2: 68 percent / tetrahydrofuran; diethyl ether / 0.33 h / -78 °C

2.1: 74 percent / PDC; activated molecular sieves / CH₂Cl₂ / 18 h / 20 °C

With dipyridinium dichromate; molecular sieve; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0014-827X(02)01261-2