4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

Base Information

• Chemical Name: 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine
• CAS No.: 637330-17-7
• Molecular Formula: C₃₇H₃₄F₃N₅O₆
• Molecular Weight: 701.702
• Mol file: 637330-17-7.mol

Synonyms:4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

Chemical Property of 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

There total 2 articles about 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trifluoroacetyl-propargyl amine (14719-21-2) + 4-amino-5-iodo-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine → 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine (637330-17-7)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1039/b301859h

Reference yield: 75.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-[3-(3-trifluoroacetamido)prop-1-ynyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (178420-75-2) → 4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine (637330-17-7)

Guidance literature:

With pyridine; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c3ob40842f

Reference yield: 87.0%

4-amino-5-(trifluoroacetamidoprop-2-ynyl)-7-(5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine (637330-17-7) → 4-amino-5-(prop-2-ynylamino)-7-(5'-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine (637330-18-8)

Guidance literature:

With sodium hydroxide; In methanol; at 18 ℃; for 20h;

DOI:10.1039/b301859h

upstream raw materials:

trifluoroacetyl-propargyl amine

4,4'-dimethoxytrityl chloride

7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-[3-(3-trifluoroacetamido)prop-1-ynyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Downstream raw materials:

4-amino-5-(prop-2-ynylamino)-7-(5'-(4,4'-dimethoxytrityl)-2'-deoxy-1'-β-D-ribofuranosyl)pyrrolo{2,3-d}pyrimidine

7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-7-deaza-2′-deoxyadenosine

7-[N-4-(methoxytrityl)-1H-imidazol-5-yl-ethylamino-3-(carbamido)propynyl]-5′-O-(4,4′-dimethoxytrityl)-3′-O-acetyl-7-deaza-2′-deoxyadenosine