8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

Base Information

Chemical Name:8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)
CAS No.:200010-60-2
Molecular Formula:C₁₉H₂₀N₂O₅S
Molecular Weight:388.444
Hs Code.:

Synonyms:8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

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Chemical Property of 8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

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Technology Process of 8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

There total 15 articles about 8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 200010-59-9
8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-oxime

: 74-88-4
methyl iodide

: 200010-60-2
8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) r.t., 1 h, 2.) r.t., overnight;

Reference yield:

: 52351-75-4
6-methoxyisatin

: 200010-60-2
8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / aq. NaOH, 30percent H₂O₂ / 24 h / Ambient temperature

2: 5 percent / BF₃*MeOH / 18 h / Heating

3: 94 percent / pyridine / Ambient temperature

4: 74 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) 80 deg C, 26 h

5: 70 percent / conc. aq. HCl / acetic acid; ethanol / 24 h / Heating

6: 91 percent / isoamyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature

7: 73 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., overnight

With pyridine; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; boron trifluoride methanol complex; sodium hydride; isopentyl nitrite; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 17422-43-4
8-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine

: 200010-60-2
8-Methoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-benzo[b]azepine-4,5-dione 4-(O-methyl-oxime)

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / pyridine / 3 h / Ambient temperature

2: 74 percent / CrO₃, aq. AcOH / Ambient temperature

3: 91 percent / isoamyl nitrite, HCl / diethyl ether / 1 h / Ambient temperature

4: 73 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., overnight

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydride; acetic acid; isopentyl nitrite; In tetrahydrofuran; diethyl ether;