6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

Base Information

Chemical Name:6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol
CAS No.:337521-22-9
Molecular Formula:C₃₇H₃₄N₂O₂
Molecular Weight:538.689
Hs Code.:

Synonyms:6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

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Chemical Property of 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

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Technology Process of 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

There total 7 articles about 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 337521-18-3
1-(6-{[tert-butyl(dimethyl)silyl]oxy}-7-methyl-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol

: 337521-22-9
6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 1285532-63-9
6-bromo-3-methyl-2-naphthol

: 337521-22-9
6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

2.2: 0.83 h / -70 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 1219689-97-0
(7-bromo-3-methoxynaphthalen-2-yl)methanol

: 337521-22-9
6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthol

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 1 h / Reflux

2.1: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 0.5 h / 160 - 180 °C

3.1: boron tribromide / dichloromethane / 2 h / -70 - 20 °C

3.2: 0 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 0 °C

5.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

5.2: 0.83 h / -70 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With 1H-imidazole; manganese(IV) oxide; n-butyllithium; tetrabutyl ammonium fluoride; boron tribromide; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 2.1: Wolff-Kishner reduction;
DOI:10.1016/j.bmc.2011.01.017