Technology Process of C17H25N5O3
There total 4 articles about C17H25N5O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Boc-Leu-NHiPr;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 5h;
C8H7N3O3;
With
dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jo300063u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.08 h / -5 - -3 °C / Inert atmosphere
1.2: Inert atmosphere
1.3: 2 h / 0 °C / Inert atmosphere
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere
3.2: pH 4
4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
4.2: 12 h / 20 °C / Inert atmosphere
With
hydrogenchloride; lithium hydroxide monohydrate; potassium carbonate; trifluoroacetic acid; potassium iodide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo300063u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
2.2: 12 h / 20 °C / Inert atmosphere
With
dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/jo300063u
