(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Base Information

Chemical Name:(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline
CAS No.:1428872-53-0
Molecular Formula:C₃₅H₄₈N₂O₇S
Molecular Weight:640.841
Hs Code.:

(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Synonyms:(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Suppliers and Price of (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

There total 20 articles about (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1428872-52-9
(4R,4aR,6S,7S,8aS)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-7-hydroxy-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

: 100-39-0
benzyl bromide

: 1428872-53-0
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Guidance literature:: (4R,4aR,6S,7S,8aS)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-7-hydroxy-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;
DOI:10.1039/c3cc41104d

Reference yield:

: C₂₁H₃₆N₂O₅

: 1428872-53-0
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

1.2: 2.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3cc41104d

Reference yield:

: C₂₁H₃₄N₄O₅

: 1428872-53-0
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-2-(tert-butoxycarbonyl)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-9-(p-toluenesulfonyl)perhydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylphosphane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

2.2: 2.5 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With sodium hydride; triethylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3cc41104d