4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Base Information

Chemical Name:4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine
CAS No.:762244-03-1
Molecular Formula:C₂₈H₄₃NO₂Si
Molecular Weight:453.74
Hs Code.:

4-benzyl-1-{3-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Synonyms:4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

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Chemical Property of 4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Chemical Property:

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Technology Process of 4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

There total 5 articles about 4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 375856-64-7
1-(4-benzyl-piperidin-1-yl)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propan-2-ol

: 74-88-4
methyl iodide

: 762244-03-1
4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0960-894X(01)00392-4

Reference yield:

: 140-67-0
Estragole

: 762244-03-1
4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / BBr₃ / CH₂Cl₂ / -78 - 20 °C

2: 38 percent / MCPBA; NaHCO₃ / CH₂Cl₂ / 20 °C

3: 82 percent / Et₃N / CH₂Cl₂ / 20 °C

4: methanol / 20 °C

5: 70 percent / NaH / tetrahydrofuran / 20 °C

With boron tribromide; sodium hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00392-4

Reference yield:

: 501-92-8
4-(prop-2-enyl)phenol

: 762244-03-1
4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 38 percent / MCPBA; NaHCO₃ / CH₂Cl₂ / 20 °C

2: 82 percent / Et₃N / CH₂Cl₂ / 20 °C

3: methanol / 20 °C

4: 70 percent / NaH / tetrahydrofuran / 20 °C

With sodium hydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00392-4